A simulation framework for reciprocal recurrent selection-based hybrid breeding under transparent and opaque simulators

Hybrid breeding is an established and effective process to improve offspring performance, while it is resource-intensive and time-consuming for the recurrent process in reality.To enable breeders and researchers to evaluate the effectiveness of competing decision-making strategies, we present a body mist modular simulation framework for reciprocal

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An update of genetic basis of PCOS pathogenesis

ABSTRACT Polycystic ovary syndrome (PCOS) is a Hockey Protective - Pants - Intermediate common and complex endocrine disorder that affects 5-20% of reproductive age women.PCOS clinical symptoms include hirsutism, menstrual dysfunction, infertility, obesity and metabolic syndrome.There is a wide heterogeneity in clinical manifestations and metabolic

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Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade

Abstract Dietary methionine interventions are beneficial to apoptosis-inducing chemotherapy and radiotherapy for cancer, while their effects on ferroptosis-targeting therapy and immunotherapy are unknown.Here we show the length of time methionine deprivation affects tumoral ferroptosis differently.Prolonged methionine deprivation prevents glutathio

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